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50 Atypical antipsychotics, including risperidone (a dopamine antagonist) and aripiprazole (a dopamine agonist), are FDA-approved drugs that have been shown to relieve irritability symptoms such as aggression and self-mutilation in adolescent autistic patients in several large clinical trials

In this study, phosphotoxic protein inhibited melanin synthesis by downregulating the expression of MITF, TRP-1, TRP-2, and tyrosinase in B16F10 cells and reducing cAMP levels (Jung et al., 2012)

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